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Engineering complex tissues requires a precisely formulated combination of cells, spatiotemporally released bioactive factors, and a specialized scaffold support. Injectable materials, particularly those delivered in aqueous solution, are considered ideal delivery vehicles for cells and bioactive factors and can also be delivered through minimally invasive methods and fill complex 3D shapes.
In this review, we examine Massage sanger Kempen materials that form scaffolds or networks capable of both replacing tissue function early after delivery and supporting tissue regeneration over a time period of weeks to months. The use of these materials for tissue engineering within the craniofacial complex is challenging but ideal as many highly specialized and functional tissues reside within a small volume in the craniofacial structures and the need for minimally invasive interventions is desirable due to aesthetic considerations.
Current biomaterials and strategies used to treat craniofacial defects are examined, followed by a review of craniofacial tissue engineering, and finally an examination of current technologies used for injectable scaffold development and drug Germany beauties Werne cell delivery using these materials.
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Reconstruction of the oral and maxillofacial complex following traumatic insult, tumor ablation, or congenital deformities remains a formidable challenge for clinicians. A myriad of tissue types and morphologically complex structures are present in a relatively small area, with the Maasage Massage sanger Kempen defects often involve multiple tissue types including the facial skeleton, special sense organs, soft tissues i.
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